A Conspiracy of Cells: One Woman's Immortal Legacy and the M

Re: A Conspiracy of Cells: One Woman's Immortal Legacy and t

Postby admin » Mon Mar 07, 2016 2:31 am

Index

Abelson, Philip, 67, 76
Adler, Rose, 31
Akeson, Richard, 103-4, 105,
106
American Type Culture Collection,
26, 30, 33, 50, 76, 100,
135-36,144
Amnion cell cultures, 25, 29,
141, 149
M. D. Anderson Hospital and
Tumor Institute, 82, 95, 96,
99, 105, 108
Tissue Culture Department,
108
Andromeda Strain, The, 64
Animal cells in culture, 17, 25,
35
Animal viruses and cancer, 4-5,
10-11
Antigens, 96, 100, 103-4, 126
description, 103
Argonne National Laboratory,
139
Auersperg, Nellie, 130
Auslandsdeutschel, 47,51
Autopsy, tissue collection during,
20-21
Bailar, John c., III, 105, 106, 121
"Banded Marker Chromosomes
as Indicators of Intraspecies
Cellular Contamination," 71
Barendsen, G. W., 138
Bassin, Robert, 64-65, 66, 67, 68,
82, 88-90, 97
Beef embryo extract in tissue culture,
16,22
Bioengineering. See Genetic
engineering
Blood cell culture, 25
Blood supply of cervical tumors,
14
Bogart, Mark, 149
Breast tumor cell cultures,
61-63,64-65,66-67,
82-83, 88-89, 95-97,
107-8, 111, 114-15
Brezhnev, Leonid, 3
Brookhaven National Laboratory,
133
Brown, Spencer, 50
Buering, Trudy, 61, 62
Cadaverous cells in tissue culture,
21-22
Cailleau, Relda, 80-82, 85-86,
104, 105-7, 108, 113-14,
116, 117, 120-21, 122-23
California State Health Department,
64
Cancer
cell characteristics of, 35
environmental causes of, 133,
134
epidermoid, 37
immature glandular cells, 37
regional types of, 134
viral causes of, 133-34. See
also Viruses and cancer
Cancer, 96
Cancer research and HeLa contamination,
34-38
Cancer researchers
attitudes of, 151-52
HeLa, use of, 24
Carcinogens, tests of, 134
Carter, Jimmy, 133
Carter administration, 134
"Case of the Unmentioned Malignancy,
The," 138-39
Cell banks, 2, 6-7, 26, 36,51,
76-78
cleanliness requirements of,
2-3, 6, 54-56
Cell Culture Laboratory. See under
University of California
at Berkeley
Cell cultures
airline shipment of, 1-2
care of, 55, 147
"evolutionary" change in,
130-31
spontaneous transformation
of,34-35
See also Tissue culture
Cell line contamination, 118, 129
causes of, 74-75
researcher attitudes re, 74-75,
129-31,151-52
See also HeLa contamination
Cell lines
descriptions of in published
studies, 78, 135
mutations of, 29
See also specific cell lines
Cell lines, identification of, 7-8
chromosome analysis, 7-8,
42-43, 56-60. See also
Marker chromosomes for
HeLa identification
chromosome banding, 11-12,
43, 58, 83
conventional karyology, 57-58
cost of, 144
isoenzyme assay, 27-28,109,
114
problems with, 25-27
See also G6PD enzyme assay
Cell markers for cell line identification,
26-27, 59, 60
Center for Disease Control, 64
Cervical cell culture, 18
Cervical tumor cell culture,
17-18
cadaverous cells, 21- 22
See also HeLa cell line
Cervical tumors
description of, 14, 21
treatment of, 14, 19-20
CH (cynomologous heart) cell
line, 128
Chang, Robert, 30
Chicken plasma in tissue culture,
16, 18,22
Child Research Center of Michigan,
7, 36, 76, 130
Chinese cell cultures, 136
Chromosome analysis and cell
line identification, 7-8,
42-43, 56-60
in fresh tissue samples, 121
Chromosome banding, 11-12,
43, 58, 83
Chromosome research, 49-50
Chromosomes, preparation for
examination, 57- 59
Colchicine, 57
Coriell, Lewis, 34, 76, 83, 84
Culliton, Barbara, 72
Daniels, David, 136, 137-38,
143, 147
Discoverer XVII satellite, 24
Down's Syndrome, 58
Duff, Jim, 1,3, 6-7, 9, 51, 78, 80,
100-1,134,140,143
Dugway Proving Ground, 49
EB33cell line, 99, 148-49
ElCo cell line, 96-97
Embryonic kidney cell culture,
25,61,62
Emory University, 49
Environmental causes of cancer,
133, 134
Enzymes and cell line identification,
36, 105, 123
See also Isoenzymes and cell
line identification
Enzymes in chromosome
banding, 58
Enzymes of viruses, 88-89
Epidermoid cancer, 37
Flandermeyer, Bob, 56-58,
60-63, 65, 84, 95, 97, 98,
110, 111, 122-23, 136-38,
141-43,147
485th U. S. Army Medical Collecting
Company, 49
Frederick Cancer Research Center.
See under National Cancer
Institute
"Fresh Pleural Effusion from a
Patient with Breast Cancer
Showing Characteristic
HeLa markers," 114-15
Gamma radiation, effect of on
cell cultures, 136
Gartler, Stanley (Stan), 27-31,
36,51,72,74,76,98,100,
130, 142
Genentech, 141-42
Genetic engineering, 141-43
"Genetic Markers as Tracers in
Cell Culture," 28
Gerwin, Brenda, 88-90
Gey, George, 14-19,20-21,
23-24,97
Gey, Margaret, 15-16, 18,97
Giemsa stain, 57, 58
Glucose metabolizing enzymes.
See G6PD enzyme assay
Index 167
G6PD enzyme assay, 8-9,
27-28,29,42,65,67,83-85,
98-100, 104, 105, 110, 123,
130
Hackett, Adeline, 61, 62
Harte, Bret, 94
Harvard University, 30
Hayflick, Leonard, 29-30, 142
Hayflick, Susan, 29
HBT3 cell line, 61-62, 63, 65, 67,
68, 75, 82-83, 88-90, 97
origins, 64
HBT39B cell line, 63, 66, 67, 75,
82-83,87
Heart cell culture, 25, 125-27
HEK cell line, 61, 62, 63, 67, 75
HeLa cell line
airline shipment of, 1- 2
European strain, 37-38
growth rate of, 18,24,33-34,
63
isoenzymes of, 27. See also
Isoenzymes and cell line
iden tifica tion
mail delivery of, 23-24
marker chromosomes of, 43,
61,67, 97, 100, 105, 109,
110-11,114,115,116,
122-23,130-31,137-38
origins, 18,36-37
tumors caused by injections of,
126-27
HeLa contamination, 27-30,33,
42-44,62-69, 84-85,
95-100,104-7,126-31,
136-38, 148-49
cancer research and, 34-38
controversy re, 108-11,
129-31
cost of, 87-91,100,145
publicity re, 67-69, 71-73,
75-76, 106-7
HeLagram, 23- 25
Heneen, W. K., 116
Hereditas, 116
Herz, Fritz, 147-48
HLA antigens, 100, 137, 138
Hoof-and mouth disease, 10, 43
Hsu, T. S., 108-9, 122-23
Institute for Medical Research,
34, 76, 83
Interferon, 141, 142
International Genetics Federation,
50
In Vitro, 78, 135
Isoenzymes and cell line identification,
27-28,109,114
Johns Hopkins Hospital, 14, 16,
20,37
Journal of the National Cancer
Institute, The, 46, 103, 105,
106,108, 111, 115, 118, 121
Journal of Virology, The, 45-46
Jungvolk, 47-48
Karyology, conventional, 57-58
Karyotypes, 60
See also Chromosome analysis
and cell line identification
Kidney cell cultures, 25, 61, 62,
136
Kubicek, Mary, 17-18,20-21,
24,97
Laboratory environments' effects
on cell cultures, 35, 130
Lacks, Henrietta, 12, 13-14,
19-21
Larynx tumor cell culture, 25
Lavappa, K. S., 108, 116, 136-37
Lawrence Berkeley Laboratory,
138
Leibovitz, Albert, 117-18, 119
Liposarcoma cell culture, 67
Litton Bionetics, Inc., 104, 106
Liver cell culture, 25,30,91, 136
Los Alamos Scientific Laboratory,
138
Los Angeles Herald Examiner, 71
Love Canal, N. Y., 134
Lung cell culture, 80
Lung tumor cell culture, 103-7
M. A. Bioproducts, 148
MAC-21 cell line, 80, 82, 85,
104-7, 147
MA160 cell line, 97-99, 148-49
cell culture contamination,
cost of, 90-91
Marker chromosomes for HeLa
identification, 43, 61, 67, 97,
100, 105, 109, 110-11, 114,
115,116,122-23,130-31,
137-38
Medical College of Wisconsin, 96
Memorial Sloan-Kettering Cancer
Center, 96
Miami Herald, 71
Microbiological Associates, Inc.,
97-98,148
Miller, Bob, 84
Moloney, John, 40-41, 42, 43-44
Montefiore Hospital, 147
National Cancer Act of 1971, 133
National Cancer Institute, 1-2,
4, 26, 39-45, 59-60, 76-77,
87, 123, 133
budget reductions, 139-40,
143
Emergency Virus Isolation Facility,
building, 41, 64, 66
Frederick Cancer Research
Center, 78
Naval Medical Center, 77
Nelson-Rees, Walter Anthony
Army career, 49-50
Cell Culture Laboratory career,
56,57,60,63-69, 144
childhood, 47-48
college career, 49, 50
disciplinary action of Tissue
Culture Association, 118-
20
disputes with fellow researchers,
80-82, 109-11, 114-17,
123-24
elected vice-president of Tissue
Culture Association, 113
funding cuts, fights against,
134-35, 139-40
"hit list" publication, 67-69,
100, 147-48
lectures on cell culture contamination,
74-76, 79-80
newspaper articles re, 71- 73
personality traits, 2-3, 51,
79-80,93-95
publishing difficulties, 45-46,
75-76
Russian cell culture identification,
5-12, 39-46
Nixon, Richard, 2, 3, 4, 39
Oakland, Calif., 53, 93-94
O'Brien, Stephen, 123, 137
Oncogenes, 143
Parks, Wade, 10-11, 12,45, 51,
151-52
Pathak, Sen, 105, 108, 111,
114-15,116-17,120,121,
122-23
Pattillo, Roland, 96
Penn State University, 136, 138,
139
Peterson, Ward, 7-8, 76,98,100,
130, 144
Pfizer Laboratories, 66
PGM/PGM3 isoenzyme assay,
27, 100, 110
Placental blood in tissue culture,
16,22
Plata, Ernest, 66,82,87-88
Pleasant, Eliza, 13
Pleasant, John, 13
Pleural effusions, 114-16,
121-22
Polio vaccine development, 24
Porter, Keith, 119, 120
Proceedings of the National
Academy of Sciences, 89
Prostate cell culture, 67, 97-98,
99, 148
Provenance, 94-95
Purple Palace, The, 41-42
See also National Cancer
Institute
Quarantine procedures for foreign
cell cultures, 10
Radiation, effect on cell cultures,
136, 139
Radiation Oncology, 137
Radiation therapy for cervical tumors,
14, 19
Rauscher, Frank, 40, 42, 133
Index 169
Researcher attitudes re cell line
contamination, 74-75,
129-31,151-52
Reverse transcriptase, 88- 89
Roller tubes, 18, 21
description, 15
Russian cell cultures, 3, 5-6, 38,
39-40, 67, 75
analysis of, 7-9, 10-12,61
contamination, cost of, 90, 91
Salk, Jonas, 125-31
Salk Institute, 125, 128
San Francisco Chronicle, 72
Schroeder, Frederick, 99
Science, 67-69,71,72,74,
75-76,90, 91, 98, 136-37,
138-39
Science News, 101
Scott and White Clinic, 117
Scripps Research Institute, 137
Seman, Gabriel, 83, 84-85,
95-96
Sex chromosomes and cell line
identification, 7-8
See also Y chromosomes
SH2 cell line, 82-84, 85
SH3 cell line, 82-84, 85, 95-96
Siciliano, Michael, 105, 108, 114,
123
Soviet-American relations, 3-4,
5,40
Spontaneous transformation,
34-35,98
Stevenson, Robert (Bob),76-79,
91, 114, 119, 135-36, 139,
147-48
Stulberg, Cyril, 36, 76, 130
TCA. See Tissue Culture
Association
Time, 141
Tissue culture
of cadaverous cells, 21- 22
methods of, 15-19
tissue collection for, 17
See also Cell cultures
Tissue Culture Association, 29,
30,69, 78, 80, 81, 107, 113,
118-20, 143
Tissue Culture Assoc. (Cont.)
Committee of Standardization,
Collection, and Distribution
of Cells and Tissues, 78
Todd, Paul, 136-37, 139
T-1 cell line, 136-39
Trypsin, 58
Tumors, immature, 37
2563 cell line, 104-5, 106
U cell line, 149
Ulceration of cervical tumors, 14
Ultraviolet light, 56
U.S. Department of Agriculture,
10
U.S.-U.S.S.R. Joint Subcommittee
on Research in Oncologic
Disease, 40-44
University of California at Berkeley,
50
Cell Culture Laboratory,
53-56, 76, 134-35
School of Public Health, 6, 50,
76
University of California at Los
Angeles medical school, 103
University of Colorado, 91
University of Indiana, 58
University of Minnesota, 23
University of Washington in
Seattle, 30
Upton, Arthur, 133
Uremia, 19-20
Vaccines, development of,
125-27
van der Veen, J., 137, 138
Vincent, Monroe (Monty), 97-98
Virologists' use of HeLa, 24
Viruses and cancer, 4-6, 10-11,
88-89,90, 133-34
research costs, 4
War on Cancer, The, 2, 3,50-51,
72-73, 142
Webber, Mukta, 91, 99
WISH cell line, 29, 91,141-42,
147
Wistar Institute, 29
X-ray therapy for cervical tumors,
19
Y chromosomes, 8, 42, 59,
98-99, 105, 138
Zhdanov, Victor, 40, 42, 44-45
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