GAO-02-809R Origin of the AIDS Virus

Re: GAO-02-809R Origin of the AIDS Virus

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Transduction of endogenous envelope genes by feline leukaemia virus in vitro
by JULIE OVERBAUGH, NORBERT RIEDEL, EDWARD A. HOOVER & JAMES I. MULLINS
Nature 332, 731 - 734 (21 April 1988); doi:10.1038/332731a0

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Transduction of endogenous envelope genes by feline leukaemia virus in vitro

JULIE OVERBAUGH, NORBERT RIEDEL*, EDWARD A. HOOVER† & JAMES I. MULLINS‡

* Department of Cancer Biology, Harvard School of Public Health, 665 Huntington Ave., Boston, Massachusetts 02115, USA

† Department of Pathology, Colorado State University, Fort Collins, Colorado 80523, USA

* Present address: Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA.

‡ To whom correspondence should be addressed.

Feline leukaemia viruses (FeLV) are exogenous retroviruses that can be detected in most cats with leukaemia, aplastic anaemia, myeloproliferative diseases and fatal immunosuppression1,2. FeLV isolates have been divided into three subgroups, based on the viral envelope-determined properties of interference and host range in vitro 3,4. FeLV-A is present in all natural isolates4,5 and is generally minimally pathogenic6,7. FeLV-B is found with FeLV-A in isolates from ~40% of natural infections and in a higher percentage of cats with lymphoma5. Following the fundamental observations of genetic reassortment of avian retroviruses with endogenous viral genes8 and the origination of lymphomagenic viruses during the ontogeny of AKR mice9, we show here that transfection of feline cells with FeLV-A DNA results in its recombination with endogenous FeLV-related sequences to produce viruses with the structural and host range properties of FeLV-B. Thus in vitro propagation of a retro virus may result in the generation of variants with very different properties.

References

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2. Hoover, E. A., Rojko, J. L. & Olsen, R. G. in Feline Leukemia (ed. Olsen, R. G.) 32−51 (CRC, Boca Raton, 1980).

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18. Rickard, C. G., Post, J. E., deNoronha, F. & Barry, L. M. J. natn. Cancer Inst. 42, 987−1013 (1969). | ChemPort |

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20. Mullins, J. I., Casey, J. W., Nicolson, M. O., Burck, K. B. & Davidson, N. J. Virol. 38, 688−703 (1981). | PubMed | ISI | ChemPort |
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