Mycoplasma – Often Overlooked In Chronic Lyme Disease

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Mycoplasma – Often Overlooked In Chronic Lyme Disease

Postby admin » Wed Dec 23, 2015 9:01 pm

Mycoplasma – Often Overlooked In Chronic Lyme Disease
by Scott Forsgren
Public Health Alert, v. 4, no. 7, 2009

NOTICE: THIS WORK MAY BE PROTECTED BY COPYRIGHT

YOU ARE REQUIRED TO READ THE COPYRIGHT NOTICE AT THIS LINK BEFORE YOU READ THE FOLLOWING WORK, THAT IS AVAILABLE SOLELY FOR PRIVATE STUDY, SCHOLARSHIP OR RESEARCH PURSUANT TO 17 U.S.C. SECTION 107 AND 108. IN THE EVENT THAT THE LIBRARY DETERMINES THAT UNLAWFUL COPYING OF THIS WORK HAS OCCURRED, THE LIBRARY HAS THE RIGHT TO BLOCK THE I.P. ADDRESS AT WHICH THE UNLAWFUL COPYING APPEARED TO HAVE OCCURRED. THANK YOU FOR RESPECTING THE RIGHTS OF COPYRIGHT OWNERS.


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Those of us with chronic Lyme disease are quite familiar with the names of the better known Lyme co-infections. Babesia, Bartonella, and Ehrlichia have become everyday words. As much as we would like to rid ourselves of these illness-producing pathogens, they have become a part of our daily struggle to regain a sense of health and wellness. Unfortunately, these are not the only co-infections seen in chronic Lyme disease. For some reason, Mycoplasma infections are not only lesser known by patients, but seemingly often overlooked by doctors as well. It is important for us, as patients, to educate ourselves on the topic of Mycoplasma and ask our practitioners how we are being evaluated and treated for these infections.

In 1987, Dr. Garth Nicolson, PhD was a professor at the University of Texas at Houston when his wife, an instructor at Baylor College of Medicine, became seriously ill and nearly died. She was diagnosed with a Mycoplasma infection, treated, and later recovered. A few years later, their daughter, who had served in the Gulf War, returned from active duty quite ill. Not only was she sick, but the symptoms that she exhibited were very similar to those that Dr. Nicolson’s wife had expressed years earlier.

At that point, Dr. Nicolson had the idea that his daughter’s illness could be the result of an infection and started to investigate his theory further. As his work progressed, he looked at Brucella, Borrelia, Ehrlichia, and other chronic intracellular infections that have the potential to cause illness and present with overlapping signs and symptoms. In Gulf War veterans that were being evaluated, approximately 45% of those that were ill had Mycoplasma infection. It was found that the infection was a particular type of Mycoplasma, namely a peculiar species called Mycoplasma fermentans.

Very little was known about this particular species of Mycoplasma at the time except that the Armed Forces Institute of Pathology and the Army had been doing research on the organism. Once this likely causative agent of Gulf War Illness (GWI) had been identified in about one-half of the GWI cases, Dr. Nicolson recommended that the Mycoplasma-infected Gulf War veterans be treated with Doxycycline. He then found himself the target of vicious attacks for making the connection between the illness and M. fermentans. Dr. Nicolson shared that “even talking about this organism was highly discouraged.” In fact, until the Gulf War, the military’s own medical school had been teaching about the dangers of M. fermentans for years.

Background

Just years earlier in Texas, prisons emerged in which many of the inmates and guards came down with neurodegenerative conditions at rates that were far from ordinary. In Huntsville, where three large State prisons are found, there were about 70 cases of ALS, numerous cases of Multiple Sclerosis, and highly unexpected numbers of Rheumatoid Arthritis cases. At that time, the term “Mystery Disease” was used to identify the unusual illnesses that so many seemed to have acquired.

Dr. Nicolson started testing prison guards and their family members and found that very high numbers of these people were testing positive for Mycoplasma fermentans. Furthermore, this appeared to be a weaponized version of the organism called M. fermentans incognitus, a specific strain of Mycoplasma that had been altered to cause more severe symptoms, to be more virulent, and to be more survivable than the naturally occurring M. fermentans. Dr. Nicolson believed that biological weapons experiments had been carried out on inmates in the Texas prison system for years in which humans had been used as guinea pigs.

As time progressed, these illnesses did not remain confined to the prisoners. Soon after the prisoners unknowingly became a part in these experiments, the prison guards became ill. Their illnesses gradually became those of their families. It was not long before these Mycoplasma-based illnesses became a broader part of the surrounding Huntsville, Texas landscape.

The Texas prisoners that came down with Amyotrophic Lateral Sclerosis (ALS) later died. In the state of Texas at the time, the state law dictated that all prisoners that died were later to be autopsied at University of Texas at Galveston. However, that was not what was happening to the prisoners who had died as a result of this horrific experimentation according to Dr. Nicolson. Through one of his former students who at the time was responsible for the autopsy service at UT Galveston, Dr. Nicolson learned that none of the bodies had been sent there. Dr. Nicolson had discovered that at least six private autopsies a week were being performed on deceased prisoners at a US Army base. The bodies were then sent to a private crematory at a secret location in central Texas. Additionally, prisoner records were destroyed. All of this, according to Dr. Nicolson, violated state law.

Though much of the evidence of this experimentation had been destroyed, a document was found in the basement of an Austin building that was viewed as the “smoking gun”. The document indicated that the Texas Prison Board, Baylor College of Medicine, and the Department of Defense were all a part of the experiments involving the Texas prisoners -- experiments that later resulted in the death of many of the inmates. According to Dr. Nicolson, some of the experiments used Mycoplasma while others utilized various “cocktails of microbial agents” such as Mycoplasma, Brucella, and DNA viruses such as Parvovirus B19. This project later become the topic of a book by Dr. Nicolson entitled Project Day Lily.


Dr. Nicolson believes that Mycoplasma fermentans is a naturally occurring microbe. However, some of the strains that exist today have been weaponized. Dr. Nicolson’s research found unusual genes in M. fermentans incognitus that were consistent with a weaponized form of the organism. Weaponizing of an organism is done in an attempt to make a germ more pathogenic, immunosuppressive, resistant to heat and dryness, and to increase its survival rate such that the germ could be used in various types of weapons. Genes which were part of the HIV-1 envelope gene were found in these Mycoplasma. This means that the infection may not give someone HIV, but that it may result in some of the debilitating symptoms of the HIV disease. Indicators of a weaponized organism were evident in the prison guards in Huntsville as well as in military personnel that were likely exposed to the infections both through military vaccinations as well as through weapons used in the Gulf War.

Mycoplasma is the number one coinfection observed in Lyme disease patients


The unfortunate reality according to Dr. Nicolson is that “once these things get out, you can’t put the genie back in the bottle”. Once these germs have been released, they are airborne infections that slowly penetrate into the population. In the case of Mycoplasma fermentans, Dr. Nicolson believes that this is exactly what happened. It may be this weaponized form of Mycoplasma that has led to the significant increases in neurodegenerative and autoimmune diseases over the last several years. Those patients with weaponized strains of these organisms are generally very sick. They may experience 60-75 signs and symptoms and are even at risk of their diseases becoming fatal.

In looking at the source of infection in the Gulf War veterans who were contracting Mycoplasma, Dr. Nicolson suggests that vaccinations appear to be the most likely mechanism through which the veterans became infected. Many military personnel that later became ill were far from the battlefields or had received the vaccinations and were never deployed. However, biological weapons sprayers were known to have been deployed by the Iraqis in the Gulf War and were used to spray the sand in Iraq and Kuwait. Gerald Schumacher, a Special Forces colonel in charge of biological weapons detection, blew the whistle on this after he retired. During the Gulf War, his group was not allowed to deploy their biological weapons detectors which led to reports that no such weapons were detected or used.

The Iraqis received a great deal of assistance on biological warfare from the United States during the Iran-Iraq Conflict. Both chemical and biologic weapons were given to them from the United States. After the Gulf War, rather than taking inventory of these weapons, they were blown up. Dr. Nicolson indicates that some of his patients have taken videos standing next to crates with Hazardous Materials tags from the United States. In the same videos, the crates are opened and weapons are clearly striped as having originated from the United States and being both chemical and biological weapons.

There were clear indicators that Iraq had offensive weapons in their arsenal. In Kuwait, many people had become quite ill. It was estimated that 25% of the population after the Gulf War had signs and symptoms which matched the symptoms of those infected with weaponized Mycoplasma. There were also a number of other chemical exposures and thus, there was never a clear indicator as to whether or not the Iraqi illnesses were caused by biologic or chemical agents.

When asking Dr. Nicolson how much he personally has been harassed for bringing much of this information to light, he shared that it has been “a horrific time”. After Dr. Nicolson exposed the Huntsville prison experiments, the University of Texas educational system attempted to fire him from his tenured and highly respected position. Dr. Nicolson shared that a tremendous amount of pressure was put on the University of Texas system to “shut him up and close his laboratory”. He was threatened on an almost daily basis with closing his lab as he continued to do his research on Mycoplasma. This became a major subject in the book Project Day Lily. Fortunately, for many of us struggling with chronic illnesses, Dr. Nicolson’s experience and knowledge continue to be a benefit in that we understand so much more than we otherwise would about this formidable foe called Mycoplasma.

Symptoms

The signs and symptoms of Mycoplasma infection are highly variable and thus it is not uncommon for a diagnosis to be entirely missed. A partial list of symptoms includes chronic fatigue, joint pain, intermittent fevers, headaches, coughing, nausea, gastrointestinal problems, diarrhea, visual disturbances, memory loss, sleep disturbances, skin rashes, joint stiffness, depression, irritability, congestion, night sweats, loss of concentration, muscle spasms, nervousness, anxiety, chest pain, breathing irregularities, balance problems, light sensitivity, hair loss, problems with urination, congestive heart failure, blood pressure abnormalities, lymph node pain, chemical sensitivities, persistent coughing, eye pain, floaters in the eyes, and many others. On Dr. Nicolson’s web site at http://www.immed.org, a full list of signs and symptoms and an illness survey
form can be found.

It doesn’t take long to see that the symptoms of Mycoplasma infections are very similar to the symptoms of Borrelia infections in chronic Lyme disease. Dr. Nicolson has looked at some of the more common neurodegenerative diseases and the infections that are associated with each. Mycoplasma is commonly found in patients with ALS, Multiple Sclerosis, Autism, Chronic Fatigue Syndrome, Rheumatoid Arthritis, Chronic Asthma, Lyme disease, and many other chronic disease conditions.

Illness / Infections Commonly Observed

Amyotrophic Lateral Sclerosis (ALS): Mycoplasma fermentans (and other species), Borrelia burgdorferi, HHV6, Chlamydia pneumoniae
Multiple Sclerosis (MS): Chlamydia pneumoniae, Mycoplasma species, Borrelia burgdorferi, HHV6, and other Herpes viruses
Alzheimer’s Disease: Chlamydia pneumoniae, Borrelia burgdorferi, HSV1 and other Herpes viruses
Parkinson’s Disease: Helicobacter pylori, coronavirus, Mycoplasma species
Autism Spectrum Disorders: Mycoplasma fermentans (and other species), Chlamydia pneumoniae, HHV6, Borrelia burgdorferi
Chronic Fatigue Syndrome: Mycoplasma pneumoniae (and other species), Chlamydia pneumoniae, Borrelia burgdoriferi
Lyme Disease: Borrelia burgdorferi, Mycoplasma fermentans (and other species), Babesia species, Bartonella species, Ehrlichia species

Chronic illnesses and infections commonly observed in each according to the work of Dr. Garth Nicolson, PhD


Characteristics

Mycoplasma are pleomorphic bacteria which lack a cell wall and as a result, many antibiotics are not effective against this type of bacteria. There are over 100 known species of Mycoplasma, but only a half dozen or so are known to be pathogenic in humans. The pathogenic species are intracellular and must enter cells to survive. Once they are inside the cells, they are not recognized by the immune system and it is difficult to mount an effective response.

They stimulate reactive-oxygen species (ROS) which damage cell membranes. They release toxins into the body. Infected cells can be stimulated to undergo programmed cell death which may result in ALS or other severe neurological presentations. 90% of ALS patients evaluated were found to have Mycoplasma infections, whereas Mycoplasma was found in 100% of ALS patients with Gulf War Syndrome, almost all of which were weaponized M. fermentans incognitus.

They are thought of as “borderline anaerobes” meaning that they generally prefer low oxygen environments. Dr. Nicolson has found that airline employees are much more susceptible to these types of infections and that symptoms worsen with frequent long flights at low oxygen tension. Mycoplasma also have some characteristics of viruses.

Mycoplasma tend to be slow growing infections and they are usually transmitted slowly. Dr. Nicolson states that “Mycoplasma can be sexually transmitted, but the infection is usually passed through far less intimate contact. Mycoplasma can be obtained through fluid exchange, and it is easily transmitted through the air.” In Gulf War veterans, the first person besides the veteran to become ill was the spouse and later, other members of the household also became ill. Not everyone is equally susceptible to Mycoplasma infections, especially those with strong immune systems who can resist infection.

As already discussed, Mycoplasma fermentans produces numerous symptoms. Those infected are rarely found to be asymptomatic. In North America, M. pneumoniae is the most common Mycoplasma seen in various diseases. In Europe, M. hominis is far more prevalent and the incidence of M. fermentans is much lower than in North America.

The potential genetic factors involved in Mycoplasma illnesses are not known. Those with immune deficiencies and other illnesses, such as cancers and degenerative diseases, are at far greater risk of infection.

Prevalence

In one study looking at Mycoplasma in patients with Chronic Fatigue Syndrome, Dr. Nicolson has observed some interesting patterns in his research. Generally, the majority of CFS patients have Mycoplasma infections. However, CFS patients infected with Borrelia burgdorferi, the punitive agent in Lyme disease, had an even higher overall Mycoplasma infection rate. As many as 75% of Lyme disease patients appear to have Mycoplasma infections, and yet Mycoplasma is often overlooked in the diagnosis and treatment of chronic lacking Lyme disease, neurodegenerative diseases, and many other chronic illnesses lacking clear origins.

Even more startling was the finding that of that of the patients infected with Borrelia, over 50% of the patients had the M. fermentans infection. Approximately 23% carried M. pneumoniae.

Chronic Fatigue patients that did not test positive for Borrelia had much more of a mixture of various species of Mycoplasma. Only 28% of the group not co-infected with Lyme disease had the M. fermentans infection. In normal, healthy controls, only 1.7% were found to have M. fermentans and at a total Mycoplasma infection rate of 5% compared to the 75% group mentioned earlier.

Dr. Nicolson notes that these findings are consistent with the fact that it is the Mycoplasma fermentans species that is more often isolated in ticks collected from the environment. The same tick that serves as the vector for Borrelia burgdorferi often also transmits M. fermentans simultaneously. Once a patient is multiply co-infected, the duration and severity of their illness both increase.

In his experience, Dr. Nicolson has found that Mycoplasma is the number one Lyme coinfection. The rate of infection with Mycoplasma in patients with Lyme disease surpasses that of Bartonella (25-40%) slightly and that of Babesia (8-20%) significantly.

According to Dr. Nicolson, a healthy immune system can generally clear M. pneumoniae infections though will have a harder time eradicating M. fermentans on its own. Healthy people can often hold these infections in check -- essentially having the infection but not expressing symptoms.

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Incidence of Various Microbes in Patients with Lyme Disease – G. L. Nicolson

Testing

Dr. Nicolson noted that Mycoplasma infections in chronic Lyme disease are often overlooked by most doctors because they simply don’t test for it. He states that those that do test for it find a much higher number of infected patients. Dr. Richard Horowitz, MD in New York finds a high incidence of M. fermentans according to Dr. Nicolson.

Sadly, however, even if patients are tested for Mycoplasma, a similar problem exists here as the one that almost all Lyme doctors and patients are aware of – namely that reliable tests do not exist. Dr. Nicolson notes that once a laboratory gets a reliable test in place, the laboratory is often shutdown. There are only a few labs left that test for Mycoplasma as a result.

In testing ticks for various microbial species, Dr. Nicolson has found a very high incidence of Mycoplasma fermentans. However, other Mycoplasma species have also been found such as M. pneumoniae and M. hominis. The incidence of these other species is far lower. “Far and away”, it is the M. fermentans species that is seen in ticks, and this probably reflects the high incidence of M. fermentans co-infections in Lyme disease.

In terms of laboratory testing, Dr. Nicolson generally recommends Viral Immune Pathology, formerly known as RedLabs. He has found that the usefulness of any given lab in testing for Mycoplasma changes regularly. In the past, Dr. Nicolson used Medical Diagnostic Laboratories (MDL) for testing, but later he and other physicians found that the testing was no longer reliable. As a result, he no longer recommends MDL.

Dr. Nicolson finds that laboratories testing for Mycoplasma are highly scrutinized by federal agencies and that may affect the way the labs test and report this type of infection.

Autoimmunity Thomas McPherson Brown, MD studied Mycoplasma at the Rockefeller Institute just before World War II. He was able to isolate bacteria from the joint fluid of a person with autoimmune arthritis and believed that the infection could have been the trigger for her disease. At the time, the organisms were too small to identify precisely, but it was later determined to be Mycoplasma.

Even then, Dr. Brown believed that Mycoplasma was very common and not easy to eradicate. He suggested using tetracycline drugs as an effective treatment for the disease. He later found that Doxycycline and Minocycline were effective at dealing with Mycoplasma. Though he garnered praise from his patients, he was generally regarded by the medical community as misguided and a trouble-maker. He died in 1989 prior to being fully vindicated. Fortunately, his work was validated through an NIH-sponsored study called MIRA or “Minocycline in Rheumatoid Arthritis".

Due to many of the characteristics of Mycoplasma, they may be responsible for the triggering of numerous autoimmune responses. As Mycoplasma replicate within cells and are eventually released, they capture antigens from the surface of the host cell and incorporate these antigens into their own membranes. This makes it almost impossible for the body to tell the difference between good and bad, between human and microbe, or between us and them. As a result, the immune system may begin to respond to these antigens now incorporated into the cell walls of the bacteria and create a condition of self-attack, or autoimmunity.


The microorganisms can produce mimicry antigens that mimic the natural host surface antigens and trigger an immune response to these antigens which may also result in autoimmune conditions through cross-reactivity. Additionally, Mycoplasma may cause cell death of host cells through a process known as apoptosis or programmed cell death.

Treatment

Though various strains of Mycoplasma have their own unique characteristics and drug responses, treatment ends to be quite similar. The variations in the strains do not appear to be a factor in a successful treatment response.

Dr. Nicolson suggests that in-vitro differences have been found but that it is not possible to easily extrapolate these findings to an in-vivo environment. Various factors including drug targeting, drug clearance, and the ability for the drug to cross into various body compartments are important considerations in treatment that cannot be examined in-vitro.

Dr. Nicolson believes that, like many other co-infections of Lyme disease, Mycoplasma cannot be fully eradicated, but that once infected, treatment becomes an ongoing “management approach”. He notes that this is a commonly understood fact and that the same is true of other organisms such as Chlamydia and Borrelia. Mycoplasma have the ability to go into a quiescent phase in intracellular locations within the body. Once in these locations, neither antibiotics, nor the immune system can effectively reach or kill the organisms.

Many people recover from Mycoplasma infections and are fine for years. They may later have an incident involving severe trauma or other significant life stressor and symptoms fully reappear within weeks to months.

Dr. Nicolson recommends that the physician adopt an initial 6-month course of treatment with no break followed by several 6-week on, 2-week off antibiotic cycles. Candidate antibiotics include: Doxycycline, Ciprofloxacin (Cipro), Azithromycin (Zithromax), Minocycline, or Clarithromycin (Biaxin). He notes that antibiotic combinations may be required if there is a limited response to single drug, and most patients require switching antibiotics at least once during their treatment. Some patients may find the addition of Flagyl to be a benefit to treatment.

In Gulf War patients, once effectively treated, the majority of patients recovered. For civilians, six months is the minimum recommended treatment length, and some patients require much longer treatment in order to recover.

Given that Mycoplasma have some characteristics of viruses, some physicians have suggested that Famvir or Ganciclovir may be added to the antibiotic therapy.

Herxheimer reactions do occur when treating Mycoplasma infections. To minimize this die-off effect where the patient generally feels much worse while on treatment, Dr. Nicolson advises using 50mg oral Benadryl taken 30 minutes before the antibiotics. He also finds that a strained blend of 1 whole lemon, 1 cup fruit juice, and 1 tablespoon of olive oil can be helpful.

Though Dr. Nicolson believes that antibiotics are the most effective approach to treating Mycoplasma infections, he has found some good natural options. In terms of natural approaches to treating Mycoplasma, Raintree Nutrition (http://www.rain-tree.com) has created several products that may be quite helpful for patients. These include Raintree Myco, Raintree A-F, and Raintree Immune Support.

Dr. Nicolson has seen evidence that Mycoplasma-specific transfer factors such as those from Chisholm Labs and others can be beneficial in some patients. He says that many natural options help in some patients, but that his experience has been that the antibiotic treatment results in the best outcomes. In many, recovery requires a push and pull between conventional and alternative treatments.

None of these treatments are a panacea. It takes a combination of things to resolve a patient’s symptoms.


One of the hallmark signs of Mycoplasma infection is fatigue. The infections lead to oxidation in the body that leads to damage of the cell membranes. Oxidation accelerates the damage to the lipids in cell membranes which impacts mitochondrial function. This leads to less energy in the cell and ultimately to a fatiguing of the larger organism due to the fact that there is less energy to support necessary cellular functions.

In patients where fatigue is due to cell membrane damage, Dr. Nicolson has found NT Factor® to be highly beneficial. NT Factor® replaces the damaged lipids and helps to restore mitochondrial function. Often, fatigue then resolves or is reduced.

Dr. Nicolson has found that oxidative therapies such as ozone can be helpful in the fight against Mycoplasma. However, he notes that this is generally palliative and does not produce the same results as the antibiotic therapy in the long-term. He finds that the oxidative therapies “are generally more cytostatic than cytotoxic”. Hyperbaric oxygen may be helpful but similarly does not appear to be a highly effective treatment in the longer-term.

In other countries, IV drips with H2O2 (hydrogen peroxide) have been used with some benefit, but Dr. Nicolson notes that these therapies, while potentially effective, are highly dangerous and not advised.

In the realm of frequency medicine and Rife therapy, Dr. Nicolson believes that the frequencies that could be used to address Mycoplasma are too similar to normal cellular frequencies. Thus, he is not certain that Rife therapy is an effective way to approach the problem.

In the nutritional realm, Dr. Nicolson finds that many patients with chronic infections are immunosuppressed and that proper nutrition is vital. He cautions against smoking and drinking. He suggests avoidance of sugars, trans-fats, and allergenic foods. He advises patients to increase their fruits, vegetables, and whole grains. Some dietary winners in supporting the immune system include cruciferous vegetables, soluble fiber-based foods such as prunes and bran, wheat germ, yogurt, fish, and whole grains.

Patients are often depleted in key vitamins and minerals. Supplementation with B-Complex, Vitamin C, Vitamin E, and CoQ-10 are often beneficial. Minerals are often necessary. Dr. Nicolson notes, however, that many people have poor absorption and may require sublingual or injectable forms of these nutrients. Amino acids, flax seed, and fish oils can provide additional support, but the best nutrition for cell membranes is NT Factor®.

Many patients with chronic illnesses have a toxic body burden of heavy metals such as mercury, lead, cadmium, and aluminum. Hair, stool, and urine testing is available through labs like Doctor’s Data (http://www.doctorsdata.com) and Genova Diagnostics (http://www.gdx.net). Dr. Nicolson has seen reports of positive results with EDTA chelation suppositories from Detoxamin (http://www.detoxamin.com) and oral chelators from Longevity Plus (http://www.longevityplus.com).

For patients using antibiotics, beneficial gut flora is often depressed. Supplementation with a high quality probiotic is important, but probiotics have to be taken two hours or longer after taking antibiotics. Natural immune support can be helpful in the form of whey proteins, transfer factors, or immune-support products such as Beyond Immuni-T from Longevity Plus.

Biolfims

Dr. Nicolson believes that biofilms are a factor in successfully treating Mycoplasma infections. In cases that are refractory to antibiotics, biofilms are likely a major factor.

In men with chronic refractory prostatitis which is infection-based, one often cannot be treated effectively with antibiotics. However, when Detoxamin (EDTA) or other agents to address the biofilms are used, it then becomes possible to treat these infections with tetracyclines. Patients quickly show functional increases and decreases in pain other symptoms.

Summary

In chronic Lyme disease, it is often difficult to know which infections are actually responsible for the persistence of illness. However, in general terms, chronic intracellular infections that change the metabolism of cells and suppress mitochondrial and other functions will lead to patients remaining in a chronically ill state. Dr. Nicolson believes that these infections must be aggressively treated. “Similar to chronic Lyme disease, the current CDC or IDSA recommendations for short-term treatment of chronic infections are simply inadequate,” he says.

Dr. Nicolson has found that there is a hierarchy of symptoms that resolve relatively quickly and those that resolve more slowly when treating Mycoplasma. Gut-associated phenomenon such as Irritable Bowel Syndrome (IBS) often resolve quickly. Other systemic signs and symptoms can resolve in an intermediate period of time from many weeks to many months. Symptoms associated with the central and peripheral nervous systems such as neuropathy and pain often resolve much more slowly. Skin sensitivity and burning sensations may take much longer to resolve. Mycoplasma infections do invade nerves, and nerve-related symptoms are among the more difficult to resolve.

Dr. Nicolson states “We keep seeing the suppression of information on Mycoplasma and similar intracellular bacterial infections. The world of Mycoplasma parallels the world of chronic Lyme disease in terms of the politics involved. Physicians are being persecuted by their medical boards as a result of bad information. It is important for us to do everything within our power to get rid of harmful, erroneous information about these diseases. Both Mycoplasma and Borrelia have been manipulated for biological weapons purposes and as a result, both are politically incorrect to discuss, work on, or do anything about. Until this changes, we won’t see any real progress.”

Resources

Professor Garth L. Nicolson is the President, Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. Born in 1943 in Los Angeles, Dr. Nicolson received his B.S. in Chemistry from University of California at Los Angeles in 1965 and his Ph.D. in Biochemistry and Cell Biology from the University of California at San Diego in 1970. Professor Nicolson has published over 580 medical and scientific papers, edited 15 books, and served on the Editorial Boards of 30 medical and scientific journals. He is also a Colonel (Honorary) of the U. S. Army Special Forces and a U. S. Navy SEAL (Honorary) for his work on Armed Forces and veterans’ illnesses. More information on Dr. Nicolson’s work can be found on his web site at http://www.immed.org

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Scott Forsgren is the editor and founder of BetterHealthGuy.com where he shares his twelve year journey through a chronic illness only diagnosed as Lyme disease after eight years of searching for answers. Scott can be reached at Scott@BetterHealthGuy.com.

Additional information on NT Factor® can be found at http://www.ntfactor.com or http://www.researchednutritionals.com.
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Re: Mycoplasma – Often Overlooked In Chronic Lyme Disease

Postby admin » Wed Dec 23, 2015 9:06 pm

Garth L. Nicolson
by Wikipedia
12/23/15

NOTICE: THIS WORK MAY BE PROTECTED BY COPYRIGHT

YOU ARE REQUIRED TO READ THE COPYRIGHT NOTICE AT THIS LINK BEFORE YOU READ THE FOLLOWING WORK, THAT IS AVAILABLE SOLELY FOR PRIVATE STUDY, SCHOLARSHIP OR RESEARCH PURSUANT TO 17 U.S.C. SECTION 107 AND 108. IN THE EVENT THAT THE LIBRARY DETERMINES THAT UNLAWFUL COPYING OF THIS WORK HAS OCCURRED, THE LIBRARY HAS THE RIGHT TO BLOCK THE I.P. ADDRESS AT WHICH THE UNLAWFUL COPYING APPEARED TO HAVE OCCURRED. THANK YOU FOR RESPECTING THE RIGHTS OF COPYRIGHT OWNERS.


Garth L. Nicolson (born October 1, 1943)[1] is an American biochemist who made a landmark scientific model for cell membrane, known as the Fluid Mosaic Model. He is the founder of The Institute for Molecular Medicine at California, and he serves as the President, Chief Scientific Officer and Emeritus Professor of Molecular Pathology. He is also Conjoint Professor in the Faculty of Science and Technology, University of Newcastle, Australia. During the outbreak of the Gulf War syndrome, he was the leading authority on the study of the cause, treatment and prevention of the disease. He was appointed Chairman of the Medical-Scientific Panel for the Persian Gulf War Veterans Conference.[2] On suspicion of the bacterium that caused the disease as a product ofbiological warfare, he made extensive scientific investigations and served as authority to the United States House of Representatives.[3] For his service he was conferred honorary Colonel of the US Army Special Forces and honorary US Navy SEAL.[4]

With S.J. Singer, Nicolson published a paper titled "The fluid mosaic model of the structure of cell membranes" in 1972,[5] which is now regarded as a classic paper in cell biology.[6][7][8]

With over 600 scientific papers, the majority of Nicolson's research is in cancer biologyand cellular properties related to aging. He had invented a number of techniques in the study of cancer, and has five US patents. In 2003 he introduced the practice of lipid replacement therapy (invented by Yechezkel Barenholz and Elishalom Yechiel in 1989) into a scientific concept.[9] He observed that the therapy had anti-aging effects, restorative potential for chronic muscle weakness (fatigue), and was beneficial to patients undergoing cancer treatments.[10] Nicolson found that at the cellular and molecular levels the actual replacement of damaged cellular lipids with undamaged lipids helped to maintain proper structure and function of cellular structures, mainly cell membrane and organelle membranes (especially those of mitochondria), and this is important for maintaning stable cellular functions.[11][12][13][14]

Biography

Nicolson was born in Los Angeles, California. He graduated from the University of California, Los Angeles in 1965 with a major in chemistry. He joined research in biochemistry at the University of California, San Diego, from where he earned his PhD in 1970. He was a USPHS Predoctoral Fellow from 1967 to 1970. During 1970–1971 he worked as Senior Research Associate in the Armand Hammer Cancer Centre of the Cancer Council Laboratory at the Salk Institute for Biological Studies, La Jolla. He became Head of the Cancer Council Laboratory, as well as Director of Electron Microscopy Laboratory in 1972. In 1974 he took the Chair of the Department of Cancer Biology, the post he held till 1976. In 1975 he was appointed Professor in the Department of Developmental and Cell Biology at the University of California, Irvine. In 1978 he additionally became Professor in the Department of Physiology and Biophysics at the College of Medicine, University of California, Irvine. In 1980 he was conferred the post Florence M. Thomas Professor of Cancer Research at the University of Texas M. D. Anderson Cancer Center, Houston, where he worked for seven years. Between 1980 and 1996 he was also Professor at the Graduate School of Biomedical Sciences, the University of Texas Health Science Center; as well as David Bruton Jr. Chair in Cancer Research, Professor and Chairman of Tumor Biology at The University of Texas M. D. Anderson Cancer Center. He was also Professor in the Department of Pathology and Laboratory Medicine at theUniversity of Texas Medical School from 1982 to 1998. During 1981–1998 he was Adjunct Professor in the Department of Pathology at the School of Veterinary Medicine, Texas A & M University. From 1989 to 1999 he was Professor in the Department of Internal Medicine at the University of Texas Medical School.[1] In 1996 he founded The Institute for Molecular Medicine at Huntington Beach in 1996.[15] He became its President, Chief Scientific Officer and Research Professor of Molecular Pathology. He also serves as Professor of Integrative Medicine at Capitol University of Integrative Medicine. Since 2003 he is also the Conjoint Professor in the Faculty of Science and Technology at the University of Newcastle, Australia.[2][3]

Contributions

Fluid Mosaic Model of cell membrane


While working as Research Associate at the Salk Institute for Biological Studies, Nicolson collaborated with S.J. Singer at theUniversity of California, San Diego. They made a seminal model for the structure of cell membranes, which they named the Fluid Mosaic Model, and published in a 12-paged paper in the February 18, 1972 issue of Science.[5] It was the first model in cell biology to be based on thermodynamics properties. Earlier descriptions of the cell membrane had serious inconsistencies with observed properties of the lipid bilayer.[16] According to the Fluid Mosaic Model, in contrast to other models, the cell membrane is composed of a single lipid bilayer which is associated with two groups of proteins. Peripheral proteins are located on the surface, while integral proteins are embedded the lipid layer. The proteins are highly varied, thus, creating a mosaic pattern. Majority of the membrane is composed of phospholipids, which exhibit fluidity like oil. The phospholids are not just stationary, but are able to move, and the proteins can move in the fluid lipid layer. These properties give the membrane flexibility.[17] The model turned out to be the foundation of modern understanding of cell membrane structure and functions. Although its basic assumptions are still true, the dynamic nature has been underestimated, and more information have been incorporated with new discoveries.[6][7][8][18][19][20][21][22]

Gulf War syndrome and controversy

After the Gulf War of 1990–1991, a number of war veterans suffered from similar illness, popularly dubbed Gulf War syndrome.[23]They indicated symptoms like chronic fatigue, headaches, memory loss, muscle pain, nausea, gastrointestinal problems, joint pain, lymph node pain, memory loss, increased chemical sensitivities and other signs and symptoms. Nicolson became one of the leading experts in the investigation of the cause and cure of the disease.[24] Initially the US government disregarded the illnesses as the aftermath of the Gulf War, such as exposure to biological or chemical warfare. Nicolson and his wife Nancy became the main voice to raise the problem.[25] They identified the causal pathogen as Mycoplasma fermentans, which was a different strain from the natural pathogen, raising the possibility that it was man-made biological weapon.[26] They successfully treated patients with multiple courses of specific antibiotics, such as doxycycline, ciprofloxacin, azithromycin, clarithromycin or minocycline.[27] Nicolson's "Written Testimony" to the US Senate in 1998 states that: "We consider it quite likely that many of the Desert Storm veterans suffering from the GWI signs and symptoms may have been exposed to chemical/biological toxins (exogenous or endogenous sources of these agents) containing slowly proliferating microorganisms (Mycoplasma, Brucella, Coxiella, etc.), and such infections, although not usually fatal, can produce various chronic signs and symptoms long after exposure."[28] While other researchers found negative results forMycoplasma infection,[29][30] Nicolson's team found definite high prevalence of Mycoplasma infections.[31]

Lipid replacement therapy

Nicolson provided a sound scientific ground for and extended the medicinal values of lipid replacement therapy (LRT), which was originally invented and patented by Yechezkel Barenholz and Elishalom Yechiel in 1989 as an anti-aging therapy. In 2003 he conceptualised the use of LRT as an improvement mitochondrial function and increased efficiency of the electron transport chain as the ways to reduced aging process and fatigue.[9] He observed that the therapy had not only anti-aging effects, but had restorative potential for chronic muscle weakness (fatigue), and was beneficial to patients undergoing cancer treatments.[10]

Awards and recognitions

• Annual Award of the Common Cause Medical Research Foundation of Canada, in 2006
• Innovative Medicine Award of Canada, in 2002
• Stephen Paget Award from Metastasis Research Society, in 1998
• Albert Schweitzer Award, in 1998
• Indo-American Society for Health & Laboratory Professionals Award, in 1996
• Colonel (Honorary) of the U. S. Army Special Forces, in 1995
• SEAL (Honorary) of the U.S. Navy Special Forces, in 1995
• Burroughs Wellcome Medal from the Royal Society of Medicine Foundation, London, in 1991
• Outstanding Faculty Award from The University of Texas Health Science Center at Houston, in 1991
• U.S. National Cancer Institute U.S.S.R. Scientist Exchange Award for Collaborative Research on Molecular and Genetic Aspects of Tumor Metastasis, in 1991
• NCI/NIH Outstanding Investigator Award, in 1987
• President of the Metastasis Research Society, 1988–1990 (Secretary-Treasurer, 1990–1998, and Vice President, 1986–1988)
• Member, Board of Directors of the American Association for Cancer Research, 1985–1988
• Annual Award of the Japan Histochemical Society, in 1976
• Upjohn Biology Education Award, in 1976
• Presidential Award of the Electron Microscopy Society of America, in 1971

References

1. "Curriculum Vitae GARTH L. NICOLSON". The Institute for Molecular Medicine. February 20, 2010. Retrieved August 6,2014.
2. "Professor Emeritus Garth L. Nicolson" (PDF). The Institute for Molecular Medicine. Retrieved August 7, 2014.
3. Nicolson, Garth L; Nicolson, Nancy L. "About the authors".Project Day Lily. Retrieved August 6, 2014.
4. "IMM – Faculty and Associate Faculty". The Institute for Molecular Medicine. Retrieved August 7, 2014.
5. Singer, S. J.; Nicolson, G. L. (1972). "The Fluid Mosaic Model of the Structure of Cell Membranes". Science 175 (4023): 720–731. doi:10.1126/science.175.4023.720.JSTOR 1733071. PMID 4333397.
6. Cherry, Richard (1991). New Techniques of Optical Microscopy and Microspectroscopy. Boca Raton, Florida: CRC Press, Inc. p. 199. ISBN 978-0-8493-7117-2. ISSN 0265-4377.
7. Luckey, Mary (2014). Membrane Structural Biology: With Biochemical and Biophysical Foundations (2 ed.). Cambridge (UK): Cambridge University Press. p. 6. ISBN 978-1-107-72933-9.
8. Jacobson, K; Sheets, E.; Simson, R (1995). "Revisiting the fluid mosaic model of membranes". Science 268 (5216): 1441–1442. doi:10.1126/science.7770769. PMID 7770769.
9. Nicoslson, Garth L (2003). "Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function". Journal of the American Nutraceutical Association 6 (3): 22–28.
10. Nicolson, GL (2005). "Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function.". Pathology Oncology Research 11 (3): 139–44. doi:10.1007/bf02893390.PMID 16195767.
11. Nicolson, Garth L.; Conklin, Kenneth A. (2007). "Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy". Clinical & Experimental Metastasis 25 (2): 161–169.doi:10.1007/s10585-007-9129-z. PMID 18058028.
12. Nicolson, Garth L. (2007). "Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function". Journal of Cellular Biochemistry 100 (6): 1352–1369. doi:10.1002/jcb.21247. PMID 17243117.
13. Nicolson, Garth L. (2010). "Lipid replacement therapy: a nutraceutical approach for reducing cancer-associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function". Cancer and Metastasis Reviews 29 (3): 543–552. doi:10.1007/s10555-010-9245-0. PMID 20717704.
14. Nicolson, Garth L.; Ash, Michael E. (2014). "Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function". Biochimica et Biophysica Acta (BBA) – Biomembranes1838 (6): 1657–1679. doi:10.1016/j.bbamem.2013.11.010.PMID 24269541.
15. "Garth Nicolson Prof.". iHealthTube. Retrieved August 6,2014.
16. Martin, Laura. "The Fluid Mosaic Model of the Cell Membrane – The Mosaic". oepnstax cnx. Retrieved August 7, 2014.
17. Ash, Michael (August 28, 2012). "A Special Note from Garth Nicolson PhD Why Lipid Replacement Therapy(LRT®) is Key to our Health". Clinical Education. Nutri-Link Ltd. RetrievedAugust 7, 2014.
18. Wiśniewska, A; Draus, J; Subczynski, WK (2003). "Is a fluid-mosaic model of biological membranes fully relevant? Studies on lipid organization in model and biological membranes". Cellular & Molecular Biology Letters 8 (1): 147–159. PMID 12655369.
19. Engelman, Donald M. (2005). "Membranes are more mosaic than fluid". Nature 438 (7068): 578–580.doi:10.1038/nature04394. PMID 16319876.
20. Kusumi, Akihiro; Fujiwara, Takahiro K.; Chadda, Rahul; Xie, Min; Tsunoyama, Taka A.; Kalay, Ziya; Kasai, Rinshi S.; Suzuki, Kenichi G.N. (2012). "Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid-mosaic model".Annual Review of Cell and Developmental Biology 28 (1): 215–250. doi:10.1146/annurev-cellbio-100809-151736.PMID 22905956.
21. Nicolson, Garth (2013). "Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure". Discoveries 1 (1): e3. doi:10.15190/d.2013.3.
22. Nicolson, Garth L. (2014). "The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40years". Biochimica et Biophysica Acta (BBA) – Biomembranes1838 (6): 1451–1466. doi:10.1016/j.bbamem.2013.10.019.PMID 24189436.
23. Nicolson, GL; Nicolson, NL (1997). "The eight myths of Operation 'Desert Storm' and Gulf War syndrome". Medicine, Conflict, and Survival 13 (2): 140–6.doi:10.1080/13623699708409329. PMID 9178600.
24. Nicolson, GL; Bruton DM, Jr; Nicolson, NL (1996). "Chronic fatigue illness and Operation Desert Storm". Journal of Occupational and Environmental Medicine 38 (1): 14–6.doi:10.1097/00043764-199601000-00003. PMID 8871324.
25. Nicolson, GL; Nicolson, NL (1997). "The eight myths of Operation 'Desert Storm' and Gulf War syndrome". Medicine, conflict, and survival 13 (2): 140–146.doi:10.1080/13623699708409329. PMID 9178600.
26. Blair, Mike (July 3, 1995). "The Government Is Lying To You -- And Ill Veterans -- About Gulf War Syndrome". The Spotlight. Retrieved August 9, 2014.
27. Nicolson, G (2001). "Continuing research into Gulf War illness".Science 292 (5518): 853b–853.doi:10.1126/science.292.5518.853b. PMID 11341275.
28. Nicolson, Garth L (November 19, 1998). "WRITTEN TESTIMONY OF Dr. Garth L. Nicolson Special Oversight Board for Department of Defense Investigations of Gulf War Chemical and Biological Incidents". U. S. Senate Hart Office Building SH-216. Retrieved August 9, 2014.
29. Gray, GC; Kaiser, KS; Hawksworth, AW; Watson, HL (1999). "No serologic evidence of an association found between Gulf War service and Mycoplasma fermentans infection". The American Journal of Tropical Medicine and Hygiene 60 (5): 752–7.PMID 10344648.
30. Lo, SC; Levin, L; Ribas, J; Chung, R; Wang, RY; Wear, D; Shih, JW (2000). "Lack of serological evidence for Mycoplasma fermentans infection in army Gulf War veterans: a large scale case-control study". Epidemiology and Infection 125 (3): 609–16. doi:10.1017/s0950268800004891. PMC 2869645.PMID 11218212.
31. Nicolson, Garth L.; Nasralla, Marwan Y.; Haier, Joerg; Pomfret, John (2002). "High frequency of systemic mycoplasmal infections in Gulf War veterans and civilians with Amyotrophic Lateral Sclerosis (ALS)". Journal of Clinical Neuroscience 9 (5): 525–529.doi:10.1054/jocn.2001.1075. PMID 12383408.
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Re: Mycoplasma – Often Overlooked In Chronic Lyme Disease

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WRITTEN TESTIMONY OF Dr. Garth L. Nicolson
Special Oversight Board for Department of Defense Investigations of Gulf War Chemical and Biological Incidents
U. S. Senate Hart Office Building SH-216
November 19, 1998

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Dr. Garth Nicolson is currently the Chief Scientific Officer and Research Professor at the Institute for Molecular Medicine in Huntington Beach, California. He was formally the David Bruton Jr. Chair in Cancer Research and Professor at the University of Texas M. D. Anderson Cancer Center in Houston, and Professor of Internal Medicine and Professor of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston. He was also Adjunct Professor of Comparative Medicine at Texas A & M University. Among the most cited scientists in the world, having published over 480 medical and scientific papers, edited 13 books, served on the Editorial Boards of 12 medical and scientific journals and currently serving as Editor of two (Clinical & Experimental Metastasis and the Journal of Cellular Biochemistry), Professor Nicolson has active peer-reviewed research grants from the U.S. Army, National Cancer Institute, National Institutes of Health, American Cancer Society and the National Foundation for Cancer Research. In 1998 he received the Stephen Paget Award from the Cancer Metastasis Research Society and the Albert Schweitzer Award in Lisbon, Portugal.

Gulf War Illnesses (GWI) have been proposed to be due to accumulated toxic insults that can result in chronic illnesses with relatively nonspecific or not unique signs and symptoms. For the most part, patients do not appear to have some new syndrome; they can be best described as patients with Chronic Fatigue Syndrome (CFS), Fibromyalgia Syndrome (FMS) or Multiple Chemical Sensitivity Syndrome (MCS) [2]. The official stance of the Department of Defense (DoD) appears to be that battlefield stress was a major factor, but most nongovernment researchers doubt that stress alone is a major cause of GWI [1, 3, 4], and it certainly does not explain how some immediate family members can present with the same signs and symptoms [2, 3, 5, 6]. GWI may be better explained as the result of multiple toxic insults to our soldiers, including those from chemical, radiological and biological sources [3, 4]. We have worked exclusively on the biological or infectious sources of patient morbidity (sickness) because whether these were obtained as primary sources or secondary opportunistic infections, they have to be identified and treated if patients are to recover from GWI [6].

Obtaining an Adequate Diagnosis and Effective Treatments for GWI

Many veterans of Operation Desert Storm face tremendous obstacles in trying to obtain an adequate diagnosis for their illnesses and then adequate care for their conditions. Up until recently, most of the emphasis in diagnosing and treating GWI within the military and VA has been on stress-related somatoform conditions, such as Post Traumatic Stress Disorder (PTSD) [7]. Since many patients do not fit this category, even with the help of military and Veterans Administration (VA) psychiatrists, and cannot be diagnosed within existing ICD-9-coded diagnosis categories, they often receive a diagnosis of unknown illness. This, unfortunately, results in their receiving reduced disability assessments, reduced benefits and essentially little or no effective treatment for GWI. It's not that they are any less sick than their compatriots who have ICD-9 diagnoses used by the DoD and DVA, they just don't fit within the military's or VA's diagnosis systems. In addition, many active-duty members of the Armed Forces are hesitant to admit that they have GWI, because they feel strongly that it will hurt their careers or result in their being medically discharged. They have good reason to fear this.

What is GWI and How is it Different from Civilian Chronic Illnesses?

GWI present as complex, multi-organ chronic signs and symptoms, including chronic fatigue, headaches, memory loss, muscle pain, nausea, gastrointestinal problems, joint pain, lymph node pain, memory loss, increased chemical sensitivities and other signs and symptoms [1-4]. Often included in this complex clinical picture are increased sensitivities to various environmental agents and enhanced allergic responses. Although CFS, FMS and now GWI have been known for years, patients have had few options for obtaining effective treatments. Unfortunately, within the DoD and VA medical systems treatments are more easily ordered on the basis of laboratory tests than on clinical observations, and the lack of clear-cut laboratory results in GWI cases tends to lend support for psychiatric diagnoses.

Over 100,000 veterans of the Persian Gulf War have been entered into the GWI registry. For the most part, this does not include immediate family members. According to one government study, GWI has spread to family members [5], and it is likely that it has also spread in the workplace. Thus diagnoses biased on PTSD appear to be a gross oversimplification of GWI [8]. Although the official position of the DoD is that family members have not contracted GWI, a U.S. Senate report [5] indicates that at least a subset of GWI patients have a transmittable illness. In support of the Senate report, we have found similar transmittable infections in Desert Storm veterans family members. In fact, clinical tests reveal that GWI family members have the same chronic infections that have been found in ~45% of the ill veterans [9-11].

Relationship of Stress to Chronic Illnesses

Patients with CFS, FMS and GWI often have cognitive problems, such as short term memory loss, problems concentrating and other psychological problems. Psychiatrists often decide in the absence of contrary laboratory findings that these conditions are caused by somatoform disorders, such as by stress, instead of organic or medical problems that can be treated with medicines or treatments that are not specific for the Central Nervous System. The evidence that physicians have offered as proof that stress or PTSD is the source of most GWI is the assumption that most veterans must have suffered from stress by virtue of the stressful environment in which they found themselves during the Gulf War [2-4]. However, most veterans do not feel that stress-related diagnoses are an accurate portrayal of their illnesses, and testimony to the House Committee on Government Reform and Oversight questions the notion that stress is the major cause of GWI [8], and the General Accounting Office (GAO) has concluded that while stress can induce some physical illness, it is not established as the major cause of GWI [12]. Stress can exacerbate chronic illnesses and suppress immune systems, but most military personnel that we interviewed indicated that the Gulf War was not a particularly stressful war, and they strongly disagreed that stress was the origin of their illnesses. However, in the absence of physical or laboratory tests that can identify possible origins of GWI or FMS and CFS, many military and VA physicians accept that stress is the cause of these chronic illnesses.

Chronic Illnesses and Chemical and/or Biological Exposures

Chemical and biological exposures occurred during the Gulf War, and many civilian patients may have been exposed to chemical and biological substances that could be the underlying initial cause of their illnesses [3]. The variable incubation times, ranging from months to years after presumed exposure, the cyclic nature of the relapsing fevers and other signs and symptoms, and the types of signs and symptoms of GWI are consistent with diseases caused by combinations of biological and/or chemical or radiological agents (Figure 1) [3]. System-wide or systemic chemical insults and/or chronic infections that can penetrate various tissues and organs, including the Central and Peripheral Nervous Systems, may be important in GWI [9-11]. When such infections occur, they can cause the complex signs and symptoms seen in CFS, FMS and GWI, including immune dysfunction. Changes in environmental responses as well as increased titers to various endogenous viruses that are commonly expressed in these patients have been seen in CFS, FMS and GWI. If infectious agents are involved, few can produce the complex chronic signs and symptoms found in these patients. One type of airborne infection that has received renewed interest of late as an important element in these disorders is mycoplasmal infections [13]. These microorganisms are now considered important emerging pathogens in causing chronic diseases as well as being important cofactors in some illnesses, including AIDS and other immune dysfunctional conditions [13, 14].

As chronic illnesses like GWI (and in some cases CFS and FMS) progress, there are a number of accompanying clinical problems, particularly autoimmune signs/symptoms, such as those seen in Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS or Lew Gehrig s Disease), Lupus, Graves Disease, Arthritis and other complex autoimmune diseases. Mycoplasmal infections can penetrate into nerve cells, synovial cells and other cell types. The autoimmune signs and symptoms can be caused when intracellular pathogens, such as mycoplasmas, escape from cellular compartments and stimulate the host's immune system. Microorganisms like mycoplasmas can incorporate into their own structures pieces of host cell membranes that contain important host membrane antigens that can trigger autoimmune responses or their surface antigens may be similar to normal cell surface antigens. Thus patients with such infections may have unusual autoimmune signs and symptoms.

Image
Figure 1. Multiple exposures (chemical, radiological, biological) or multifactorial causes may have resulted in GWI in susceptible individuals. Chemical exposures alone could also be responsible for Multiple Chemical Sensitivity Syndrome (MCS) or Organophosphate-Induced Delayed Neurotoxicity (OPIDN) (from Reference 3).

Microorganisms as Important Agents or Cofactors in Chronic Diseases

Some species of mycoplasmas, such as M. fermentans, M. penetrans, M. pneumoniae, M. genitalium, M. pirum and M. hominis, among others, have been closely associated with various human diseases [13, 14]. In addition, chronic infections caused by Brucella or Coxiella can also cause similar signs and symptoms. Do these agents cause or are co-factors in CFS, FMS or GWI? They can certainly be important in causing morbidity seen in patients with chronic illnesses [14]. If so, is there any evidence for mycoplasmal infections in CFS, FMS or GWI patients? In a majority of FMS, CFS and GWI patients examined we [9-11] and others, principally Dr. Daryl of the University of California College of Medicine, Irvine, and a commercial laboratory in Los Angeles [15] have documented mycoplasmal blood infections that can explain much of the chronic signs and symptoms seen in GWI [9-11]. In our studies on GWI, we have found mycoplasmal infections in the blood of about one-half of patients (91/200), and these patients were found to have predominantly one infectious species of mycoplasma, M. fermentans [9, 10], compared to ~60% of mycoplasma-positive civilians with CFS, FMS or Rheumatoid Arthritis, where several different pathogenic mycoplasma species have been found [11, 16]. The tests that we use to identify infections, Forensic Polymerase Chain Reaction [11, 16] and Nucleoprotein Gene Tracking [9-11], are very sensitive and highly specific tests compared to the relatively insensitive antibody tests that are currently used to assay for systemic mycoplasmal infections. We recently received a DoD contract to train scientists and physicians to perform these tests, including the training of staff from the Armed Forces Institute of Pathology and Walter Reed Army AMC.

Inadequate Responses of the DoD and DVA to GWI

Has the DoD responded to the published studies on microorganism infections in GWI patients? They did award us with a small training grant to teach the techniques to DoD and non-DoD scientists, but in general, the response has been inadequate and mainly denial that what we and others have found is important in GWI, even though the majority of patients diagnosed with chronic infections and treated with antibiotic protocols developed by us recover from their illness. In response to our publications and formal lectures at the DoD (in 1994 and 1996) and DVA (in 1995), the DoD stated in letters to various members of Congress and to the press that this type of infection is commonly found, not dangerous and not even a human pathogen, and our results have not been duplicated by other laboratories. These statements could not be further from the truth. The Uniformed Services University of the Health Sciences has been teaching its medical students for years that this type of infection is very dangerous and can progress to system-wide organ failure and death [17]. In addition, the Armed Forces Institute of Pathology (AFIP) has been publishing for years that this type of infection can result in death in nonhuman primates [18] and in man [17]. The AFIP has also suggested treating patients with this type of infection with doxycycline [19], which is one of the antibiotics that we have recommended [9-11, 20-22]. Then why did the DVA issue guidelines stating that GWI patients should not be treated with antibiotics like doxycycline, even though in a significant number of patients it has been shown to be beneficial [9, 10]? In response to the comments that our tests have not been duplicated, certified diagnostic clinical laboratories, Immunosciences Laboratories of CA [15] and Medical Diagnostic Laboratories of NJ have been conducting diagnostic tests on mycoplasmal infections in blood of GWI and CFS patients, and they are obtaining similar results. Thus our results have been replicated by certified commercial laboratories and published in the medical literature. The DoD and DVA have also stated that we have not cooperated with them or the CDC in studying this problem. This is not true. We have done everything possible to cooperate with the DoD, DVA and CDC on this problem, and we even published a letter in the Washington Post on 25 January 1997 indicating that we have done everything possible to cooperate with government agencies on GWI issues. We formally invited DoD and DVA scientists and physicians to the Institute for Molecular Medicine to learn our diagnostic procedures on 23 December 1996 at a meeting convened at Walter Reed AMC by MG Leslie Burger at the request of Congressman Norman Dicks (D-WA). We have been and are fully prepared to share our data and procedures with government scientists and physicians. Although government laboratories can test for mycoplasmal infections and have been conducting their own examination of mycoplasmal infections in GWI patients, they are using relatively insensitive, outdated antibody tests or conventional molecular biological tests, and we would not expect them to detect the infection by these procedures. To correct this situation we received a small training contract from the DoD to train DoD scientists in our new techniques, and the training was completed on January 30, 1998. Recently the DVA has recognized the value of our work and will initiate on 1 January 1999 VA Cooperative Clinical Trial #475, a diagnostic and treatment trial that focuses on mycoplasmal infections in GWI and their treatment with doxycycline using essentially a regimen that we published in 1995 [20].

Successful Treatment of GWI Mycoplasmal Infections

We have found that mycoplasmal infections in GWI, CFS, FMS and RA can be successfully treated with multiple courses of specific antibiotics, such as doxycycline, ciprofloxacin, azithromycin, clarithromycin or minocycline [9-11, 20-22], along with other nutritional recommendations. Multiple treatment cycles are required, and patients relapse often after the first few cycles, but subsequent relapses are milder and most patients eventually recover [9, 10]. In contrast, in nondeployed, healthy adults the incidence of mycoplasma-positive tests were ~6% [11]. We found that 87 mycoplasma-positive GWI patients on antibiotic therapy relapsed within weeks after the first 6-week cycle of therapy, but 69/87 recovered after up to six cycles of therapy and 18/87 are still undergoing therapy. GWI patients who recovered from their illness after several (3-7) 6-week cycles of antibiotic therapy were retested for mycoplasmal infection and were found to have reverted to a mycoplasma-negative phenotype [9, 10]. We hypothesize that the therapy takes a long time because of the microorganisms involved are slow-growing and are localized deep inside cells in tissues, where it is more difficult to achieve proper antibiotic therapeutic concentrations. As stated above, multiple cycles of therapy result in eventual recovery in a high percentage of mycoplasma-positive GWI patients. Although anti-inflammatory drugs can alleviate some of the signs and symptoms of GWI, the signs and symptoms appear to quickly return after discontinuing drug use. If the effect was due to an anti-inflammatory action of the antibiotics, then the antibiotics would have to be continuously applied and they would be expected to eliminate only some of the signs and symptoms of GWI. In addition, not all antibiotics, even those that have anti-inflammatory effects, appear to work. Only the types of antibiotics that are known to be effective against mycoplasmas are effective; most have no effect at all on the signs and symptoms of GWI/CFS/FMS/RA, and some antibiotics make the condition worse. Thus the antibiotic therapy does not appear to be a placebo effect, because only a few types of antibiotics are effective and some, like penicillin, make the condition worse. We also believe that this type of infection is immune-suppressing and can lead to other opportunistic infections by viruses and other microorganisms or increases in endogenous virus titers. The percentage of mycoplasma-positive GWI patients overall is likely to be somewhat lower than found in our studies (~45%). This is reasonable, since GWI patients that have come to us for assistance are probably more advanced patients (with more progressed disease) than the average patient. Although we have been criticized for not conducting double-blinded, controlled clinical studies on large numbers of patients, such studies are quite labor intensive and very expensive, and all of our studies were conducted without any government support or help whatsoever. Although our studies do not involve controlled patient populations, such as all veterans that served in a single unit compared to similar numbers of nondeployed personnel from the same unit, such controlled populations can only be studied with the help and financial assistance of the DoD and DVA. Recently the DVA has initiated a controlled clinical trial (CSP #475) involving 18 VA medical institutions that will test the usefulness of antibiotic treatment of mycoplasma-positive GWI patients. This clinical trial is based completely on our research and publications on the diagnosis and treatment of chronic infections in GWI patients [9, 10, 20-22].

What has the DoD Stated About Our Procedures and Results?

The recent comments of Mr. Bernard Rostker, Special Assistant to the Deputy Secretary of Defense for Gulf War Illnesses and more recently Assistant Secretary of the Army, at the 17th Town Hall meeting on Gulf War Illnesses at Camp Pendleton on 23 September 1998 indicate that the DoD is still trying to bury the issue of infectious diseases and GWI. According to the comments of Mr. Rostker as related by two participants (S. and L. Dudley of San Diego, CA) in their TV interview after the meeting, "Dr. Shyh-Ching Lo, Armed Forces pathologist, is going to publish that he was not able to reproduce Nicolson's results and that Nicolson was not cooperating in terms of not obtaining those results in the medical community and in fact was hampering it." This is not the truth. In fact, two commercial laboratories that we assisted in setting up similar clinical tests, one in California and one in New Jersey, have confirmed our mycoplasma results in Gulf War Illness patients. It seems that only the AFIP cannot apparently repeat the results, which is why we were awarded a small contract to train them in January of this year. They have never submitted their data for peer-review, even after several years. We have published our data [9-11, 20-22], and we have also published that blood for analysis must be at refrigerator temperatures and prepared very quickly in order to prevent mycoplasma deterioration [11]. GWI patients have told me (and Dr. Lo even admitted to this to patients) that the AFIP does not store blood properly, and we claim that they do not do the tests properly, which could be why the DoD has never obtained accurate data on mycoplasmal infections in GWI patients.

The DoD pronouncements on the lack of chronic infections (Mycoplasma, Brucella, Coxiella, etc.) in GWI and CFS patients flies in the face of published data from university and nongovernmental laboratories. Mr. Rostker stated that "the DoD/VA had initiated a program with Dr. Nicolson to train labs on his testing techniques but were unable to get Dr. Nicolson to send blood samples as he promised to do and were unable to identify the techniques he used and were unable to find the mycoplasma in the blood." These are complete distortions and untruths. The laboratories involved in these studies are using blood from NIH not my laboratory, and these laboratories can and have been detecting mycoplasmal infections using the techniques that we taught them. Why would high officials use untruths and distortions in an effort to cast nongovernmental scientists in an unfavorable light? Was this done to cover up a completely inadequate government response to GWI? And why are they still going to such great lengths to cover this up more than 8 years after Dessert Storm? We have been able to help thousands of GWI patients after years of suffering obtain a diagnosis and treatment and recover from their illnesses, and these same patients were not even given a diagnoses or effective treatments by DoD or VA medical facilities. If we are wrong, then why are our patients doing better than the DoD/VA patients with GWI? Why then is the DVA willing to allocate more than $12,000,000 to conduct a cooperative clinical trial based entirely on our diagnosis and treatment protocol for treating mycoplasmal infections?

Potential Sources of Exposures That Could Have Caused GWI

We consider it quite likely that many of the Desert Storm veterans suffering from the GWI signs and symptoms may have been exposed to chemical/biological toxins (exogenous or endogenous sources of these agents) containing slowly proliferating microorganisms (Mycoplasma, Brucella, Coxiella, etc.), and such infections, although not usually fatal, can produce various chronic signs and symptoms long after exposure. This would account for the illnesses being passed to immediate family members. The DoD has maintained that Iraqi offensive Chemical and Biological Weapons (CBW) were not released during or after the Gulf War, but over 14,000 Chemical Weapons alarms sounded during but not before the conflict and we did not have detection equipment forward deployed to be able to determine whether Biological Weapons were present. The Iraqi armed forces were operating under Soviet War Doctrine, which stresses offensive use of combinations of Chemical and Biological Weapons together with conventional weapons [23]. Evidence presented to Congress [8] indicated that it was extremely likely that Chemical Weapons were released during and certainly after the conflict when bunkers containing CBW were destroyed. Although chemical and/or radiological exposure(s) can result in somewhat similar signs and symptoms to those found in GWI, this does not explain the apparent contagious nature of GWI and the delayed appearance of similar signs and symptoms in immediate family members. Fortunately, the types of slow-growing, chronic infections found in a subset of GWI patients can be diagnosed and successfully treated using our published protocols [9-11, 20-22].

There were several potential sources of chronic biological agents in the Persian Gulf Theater [9, 23]. First, deployed soldiers were given multiple inoculations, in some cases with experimental vaccines in unproved immunization schemes, such as vaccines that were given all at once instead of using an appropriate schedule of inoculations over months or years. Multiple vaccinations given simultaneously can result in immunosuppression and leave an individual susceptible to opportunistic infections. Some of these experimental vaccines could also have been contaminated with small amounts of slow-growing microorganisms. In fact, some of the vaccine lots to be sent to the Gulf were removed because of "microorganism contamination." Next, the Iraqis were known to have extensive stockpiles of Biological Weapons and the potential to deliver these weapons offensively, at short range in modified Italian-made biological sprayers that deliver Biological Weapons onto the sand to create exclusionary zones or 'biological minefields' and at long range in modified SCUD-B (SS-1) missiles with 'airburst' warheads or sprayers carried by aircraft. As mentioned above, many of the storage and factory facilities where CBW were stored were destroyed immediately up to, during and after the Desert Storm ground offensive, releasing plumes containing these agents high in the atmosphere where they could be carried downwind ('blow-back' exposures) to our lines. These and other possible mechanisms of potential exposure must be carefully examined, not categorically dismissed by DoD personnel in Washington DC with little first-hand knowledge of the conditions on the ground. A number of possible reasons exist that could explain why the DoD and DVA deny that our forces were exposed to CBW agents during the Gulf War, but this does not rationalize the poor responses to GWI casualties [23].

Conclusions and Suggestions

It seems counterproductive to continue the contentious battle over whether or not our forces were exposed to toxic agents in the Gulf Theater of Operations and whether or not they have chronic infections in their blood. I firmly believe that it is now time to diagnose and treat the casualties irrespective of how politically painful the truth may be. Our lack of an adequate response to GWI may dictate how our weaknesses are assessed and exploited in any future conflict [24]. Therefore, we need to act. I have the following suggestions:

1. We must stop the denial that immediate family members do not have GWI from the war. Denial that this has occurred has only angered veterans and their families and created a serious public health problem, including spread of the illness to the civilian population and contamination of our blood supply.

2. The ICD-9-coded diagnosis system used by the DoD and DVA to determine illness diagnosis must be overhauled. The categories in this system have not kept pace with new medical discoveries in the diagnosis and treatment of chronic illnesses. This has resulted in large numbers of patients from the Gulf War with undiagnosed illnesses who cannot obtain treatment or benefits for their medical conditions.

3. Denying claims and benefits by assigning partial disabilities due to PTSD should not be continued in patients that have organic (medical) causes for their illnesses. For example, patients with chronic infections that can take up to or over a year to successfully treat should be allowed benefits.

4. Research efforts must be increased in the area of chronic illnesses. Unfortunately, federal funding for such illnesses is often rebudgeted or funds removed. For example, Dr. William Reeves of the CDC in Atlanta recently sought protection under the Federal Whistle Blower's Act after he exposed such misappropriation of funds at the CDC. It is estimated that over 3% of the adult U.S. population suffers from chronic illnesses similar to GWI, yet there are few federal dollars available for research on the diagnosis and treatment of these chronic illnesses, even though each year Congress allocates such funds.

5. Senior DoD and DVA personnel must be held accountable for the utter mismanagement of the entire GWI problem. This has been especially apparent in the continuing denial that chronic infections could play a role in GWI and the denial that immediate family members could have contracted their illnesses from veterans with GWI. This has resulted in sick spouses and children being turned away from DoD and DVA facilities without diagnoses or treatments. The responsibility for these civilians must ultimately be borne by the DoD and DVA. I believe that it is now accountability time. The files must be opened so the American public has a better idea how many veterans and civilians have died and how many have become sick because of an inadequate response to this health crisis.

References Cited

1 Murray-Leisure, K., Daniels, M.O., Sees, J., Suguitan, E., Zangwill, B., Bagheri, S., Brinser, E., Kimber, R., Kurban, R. Greene, W.H. Mucocutaneous-Intestinal-Rheumatic Desert Syndrome (MIRDS). Definition, histopathology, incubation period, clinical course and association with desert sand exposure. Intern. J. Med. 1997; 1: 47-72.

2 Nicolson, G.L. and Nicolson, N.L. Chronic Fatigue Illness and Operation Desert Storm. J. Occup. Environ. Med. 1996; 38: 14-16.

3 Nicolson, G.L., Nasralla, M, Hier, J. and Nicolson, N.L. Gulf War Illnesses: role of chemical, radiological and biological exposures. In: War and Health, H. Tapanainen, ed., Helinsiki, in press, 1998.

4 Nicolson, G.L., Hyman, E., Korényi-Both, A., Lopez, D.A, Nicolson, N.L., Rea, W., Urnovitz, H. Progress on Persian Gulf War Illnesses: reality and hypotheses. Intern. J. Occup. Med. Tox. 1995; 4: 365-370.

5 U. S. Congress, Senate Committee on Banking, Housing and Urban Affairs, U. S. chemical and biological warfare-related dual use exports to Iraq and their possible impact on the health consequences of the Persian Gulf War , 103rd Congress, 2nd Session, Report May 25, 1994.

6 Nicolson, G.L. Chronic infections as a common etiology for many patients with Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. Intern. J. Med. 1998; 1: 42-46.

7 NIH Technology Assessment Workshop Panel. The Persian Gulf Experience and Health. J. Amer. Med. Assoc. (JAMA) 1994; 272: 391-396.

8 U. S. Congress, House Committee on Government Reform and Oversight, Gulf War veterans : DOD continue to resist strong evidence linking toxic causes to chronic health effects, 105th Congress, 1st Session, Report 105-388, 1997.

9 Nicolson, G.L. and Nicolson, N.L. Diagnosis and treatment of mycoplasmal infections in Gulf War Illness-CFIDS patients. Intern. J. Occup. Med. Immunol. Tox. 1996; 5: 69-78.

10 Nicolson, G.L., Nicolson, N.L. and Nasralla, M. Mycoplasmal infections and Chronic Fatigue Illness (Gulf War Illness) associated with deployment to Operation Desert Storm. Intern. J. Med. 1997; 1: 80-92.

11 Nicolson, G.L., Nasralla, M, Hier, J. and Nicolson, N.L. Diagnosis and treatment of chronic mycoplasmal infections in Fibromyalgia Syndrome and Chronic Fatigue Syndrome: relationship to Gulf War Illness. Biomed. Therapy 1998; 16: 266-271.

12 U. S. General Accounting Office, Gulf War Illnesses: improved monitoring of clinical progress and reexamination of research emphasis are needed. Report GAO/SNIAD-97-163, 1997.

13 Baseman, J.B. and Tully, J.G. Mycoplasmas: Sophisticated, reemerging, and burdened by their notoriety. Emerg. Infect. Diseases 1997; 3: 21-32.

14 Cassell, G.H. and Cole, B.C. Mycoplasmas as agents of human disease. New Eng. J. Med. 1981; 304: 80-89.

15 Choppa, P.C., Vojdani, A., Tagle, C., Andrin, R. and Magtoto, L. Multiplex PCR for the detection of Mycoplasma fermentans, M. hominis and M. penetrans in cell cultures and blood samples of patients with Chronic Fatigue Syndrome. Mol. Cell Probes 1998; 12: 301-308.

16 Hier, J., Nasralla, M. and Nicolson, G.L. Detection of mycoplasmal infections in blood of patients with rheumatoid arthritis. Brit. J. Rheumatol. 1998; in press.

17 Lo, S.-C., Dawson, M.S., Newton, P.B., Sonoda, A.A., Shih, W.-K., Engler, W.F., Wang, R.Y.-H. and Wear, D.J. Association of the virus-like infectious agent originally reported in patients with AIDS with acute fatal disease in previously healthy non-AIDS patients. Amer. J. Trop. Med. Hyg. 1989; 41: 364-376.

18 Lo, S.-C., Wear, D.J., Shih, W.-K., Wang, R.Y.-H., Newton, P.B. and Rodriguez, J.F. Fatal systemic infections of nonhuman primates by Mycoplasma fermentans (incognitus strain). Clin. Infect. Diseases 1993; 17(Suppl 1): S283-S288.

19 Lo, S.-C., Buchholz, C.L., Wear, D.J., Hohm, R.C. and Marty, A.M. Histopathology and doxycycline treatment in a previously healthy non-AIDS patient systemically infected by Mycoplasma fermentans (incognitus strain). Mod. Pathol. 1991; 6: 750-754.

20 Nicolson, G.L. and Nicolson, N.L. Doxycycline treatment and Desert Storm. J. Amer. Med. Assoc. (JAMA) 1995; 273: 618-619.

21 Nicolson, G.L. and Nicolson, N.L. Mycoplasmal infections--Diagnosis and treatment of Gulf War Syndrome/CFIDS. CFIDS Chronicle 1996; 9(3): 66-69.

22 Nicolson, G.L. Considerations when undergoing treatment for chronic infections found in Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. (Part 1). Antibiotics Recommended when indicated for treatment of Gulf War Illness/CFIDS/FMS (Part 2). Intern. J. Med. 1998; 1: 115-117, 123-128.

23 Nicolson, G.L. and Nicolson, N.L. Gulf War Illnesses: complex medical, scientific and political paradox. Medicine Conflict & Survival 1998; 14: 156-165.

24 Nicolson, G.L. and Nicolson, N.L. The eight myths of Operation Desert Storm and Gulf War Syndrome. Medicine Conflict & Survival 1997; 13: 140-146.

Under penalty of perjury, I swear that the statements above are true and correct to the best of my knowledge, information and belief.

Garth L. Nicolson
Chief Scientific Officer
The Institute for Molecular Medicine
and
Professor of Internal Medicine

Address:
The Institute for Molecular Medicine
15162 Triton Lane
Huntington Beach, CA 92649
Tel (714) 903-2900 Fax (714) 379-2082
Institute for Molecular Medicine Website: http://www.immed.org
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